Selected Publications

Research Articles:

#Corresponding authors
*Contributed equally

2019​

  • Chiu DK*, Tse AP*, Law CT, Xu IM, Lee D, Chen M, Lai RK, Yuen VW, Cheu JW, Ho DW, Wong CM, Zhang H, Ng IO#, Wong CC#. Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway . Cell Death & Disease. Accepted.  

  • Lai LW, Lee D, Law DC, Shen J, Chin DW, Tsang FH, Wong CL, Ng IO, Wong CC#, Wong CM#. Genome-wide CRISPR/Cas9 library screening identified PHGDH as critical driver for Sorafenib resistance in HCC. Nature Communications. 2019 Oct 15;10(1):4681. 

  • Shen J, Chen M, Lee D, Law C, Wei L, Tsang FH, Chin WC, Cheng CL, Lee JM, Ng IO, Wong CC#, Wong CM#. Histone Chaperone FACT complex mediates oxidative stress response to promote liver cancer progression. GUT. 2019 Aug 22. pii: gutjnl-2019-318668.

  • Tsang FH, Law CT, Tang TC, Cheng CL, Chin DW, Tam WV, Wei L, Wong CC, Ng IO, Wong CM. Aberrant super-enhancer landscape in human hepatocellular carcinoma. Hepatology. 2019 Jun;69(6):2502-2517.

  • Chen F, Zhou J, Li Y, Zhao Y, Yuan J, Cao Y, Wnag L, Zhang Z, Zhang B, Wang CC, Cheung TH, Wu Z, Wong CC, Sun H, Wang H. YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells. EMBO J. 2019 Apr 12. pii:e99727. doi: 10.15252/embj.201899272.

  • Lee D, Xu IM, Chiu DK, Leibold J, Tse AP, Chan CY, Lai RK, Chin DW, Chan DF, Cheung TT, Chok SH, Wong CM, Lowe SW, Ng IO#, Wong CC#. Induction of oxidative stress via inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma. Hepatology. 2019 Apr; 69(40):1768-1786.  

  • Law CT, Wei L, Tsang FH, Chan CY, Xu IM, Lai RK, Ho DW, Lee JM, Wong CC, Ng IO, Wong CM. HELLS regulates chromatin remodeling and epigenetic silencing of multiple tumor suppressor genes in human hepatocellular carcinoma. Hepatology. 2019 May;69(5):2013-2030.

2018

  • Tse AP, Sze KM, Shea QT, Chiu EY, Tsang FH, Chiu DK, Zhang MS, Lee D, Xu IM, Chan CY, Koh H, Wong CM, Zheng YP, Ng IO, Wong CC. Hepatitis transactivator protein X promotes extracellular matrix modification through HIF/LOX pathway in liver cancer. Oncogenesis. 2018 May 25;7(5):44

2017

  • Chen M, Wei L, Law CT, Tsang FH, Shen J, Cheng CL, Tsang LH, Ho DW, Chiu DK, Lee JM, Wong CC, Ng IO, Wong CM. RNA N6-methyladenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent post-transcriptional silencing of SOCS2. Hepatology. 2018 Jun;67(6):2254-2270.

  • Chiu DK, Tse AP, Xu IM, Cui JD, Lai RK, Li LL, Koh H, Tsang FH, Wei LL, Wong CM, Ng IO#, Wong CC#. Hypoxia inducible factor-1 (HIF-1) promotes myeloid-derived suppressor cell accumulation through ENTPD2/CD39L1 in hepatocellular carcinoma­­­­. Nature Communications. 2017 Sep 11;8(1):517.

  • Wei L, Chiu DK, Tsang FH, Law DC, Cheng CL, Au SL, Lee JM, Wong CC, Ng IO, Wong CM. Histone methyltransferase G9a promotes liver cancer development by epigenetic silencing of tumor suppressor gene RARRES3. Journal of Hepatology. 2017 May 19. Pii: S0168-8278 (17)32051-2.

  • Lee D*, Xu IM*, Chiu DK*, Lai RK, Tse AP, Li LL, Law CT, Tsang FH, Wei LL, Chan CY, Wong CM, Ng IO#, Wong CC#. Methylenetetrahydrofolate dehydrogenase 1-like of the folate cycle confers hepatocellular carcinoma metabolic advantages. Journal of Clinical Investigation. 2017 May; 127(5): 1856-1872.​

    • Invited Commentary: Lee D, Wong CC. The folate cycle is a new metabolic weakness of cancer. Molecular & Cellular Oncology. In Press.

  • Cui CP, Wong CC, Kai AK, Ho DW, Lau EY, Tsui YM, Chan LK, Cheung TT, Chok KS, Chan AC, Lo RC, Lee JM, Lee TK, Ng IO. SENP1 promotes hypoxia-induced cancer stemness by HIF-1α deSUMOylation and SENP1/HIF-1α positive feedback loop. Gut. 2017 Mar 3. pii: gutjnl-2016-313264.

2016

  • Chiu DK, Xu IM, Lai RK, Tse AP, Wei LL, Koh H, Li LL, Lee D, Lo RC, Wong CM, Ng IO#, Wong CC#. Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) Ligand 26. Hepatology. 2016 Sep;64(3):797-813.

  • Kai AK, Chan LK, Lo RC, Lee JM, Wong CC, Wong CM, Ng IO. Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma. Hepatology. 2016 Aug;64(2):473-87.

  • Ma W, Sze KM, Chan LK, Lee JM, Wei LL, Wong CM, Lee TK, Wong CC, Ng IO. RhoE/ROCK2 regulates chemoresistance through NFκB/IL-6/STAT3 signaling in hepatocellular carcinoma. Oncotarget. 2016 Jul 5;7(27):41445-41459.

  • Lai RK, Xu IM, Chiu DK, Tse AP, Wei LL, Law CT, Lee D, Wong CM, Wong MP, Ng IO#, Wong CC#. NDUFA4L2 fine-tunes oxidative stress to promote hepatocellular carcinoma. Clinical Cancer Research. 2016 Jun; 22(12):3105-17.

  • Wong CM, Wei L, Law CT, Ho DW, Tsang FH, Au SL, Sze KM, Lee JM, Wong CC, Ng IO. Up-regulation of histone methyltranserase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis. Hepatology. 2016 Feb; 63(2):474-87.

  • Xu IM, Lai RK, Lin SH, Tse AP, Chiu DK, Wong CM, Cai Z, Wong CC#, Ng IO#. Transketolase counteracts oxidative stress to drive cancer development. Proceedings of National Academy of Sciences. 2016 Feb;113(6):E725-34.

  • Wong CM, Lai W, Law CT, Ho DW, Tsang FH, Au SL, Sze KM, Lee JM, Wong CC, Ng IO. Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis. Hepatology. 2016 Feb;63(2):474-87.

2015

  • Wong CM, Wei L, Au SL, Fan DN, Zhou Y, Tsang FH, Law CT, Lee JM, He X, Shi J, Wong CC, Ng IO. MiR-200b/200c/429 subfmaily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis. Oncotarget. 2015 May 30;6(15):13658-70.

  • Leung CO, Wong CC, Fan DN, Kai AK, Tung EK, Xu IM, Ng IO, Lo RC. PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma. Oncotarget. 2015 May; 6 (13): 10880-92.

  • Tsang FH, Au SL, Wei L, Fan DN, Lee JM, Wong CC, Ng IO, Wong CM. Long non-coding RNA HOTTIP is frequently up-regulated in hepatocellular carcinoma and is targeted by tumor suppressive miR-125b. Liver International. 2015 May; 35 (5):1597-606.

2014

  • Wong CC#*, Au SL*, Tse AP, Xu IM, Lai RK, Wei LL, Fan DN, Tsang FH, Wong CM, Ng IO#. Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis. PLoS ONE. 2014 Dec 26;9(12):e115036.

  • Wong CC#, Tse PW, Huang Y, Zhu Y, Chiu DK, Lai RK, Au SL, Kai AK, Lee JM, Wei LL, Tsang FH, Lo RC, Shi J, Zheng Y, Wong CM, Ng IO#. Lysyl Oxidase-Like 2 is critical to tumor microenvironment and metastatic niche formation in hepatocellular carcinoma. Hepatology. 2014 Nov;60(5):1645-58.

2013

  • Au SL, Wong CC, Lee JM, Wong CM, Ng IO. EZH2-mediated H3K27me3 involves in epigenetic repression of Deleted in liver cancer 1 in human cancers. PLoS ONE. 2013 Jun 27;8(6):e68226.

  • Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer Research. 2013 Jun 1;73(11):3285-96.

  • Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Molecular Cancer Research. 2013 May;11(5):456-66.

  • Hubbi ME, Kshitiz, Gilkes DM, Rey S, Wong CC, Luo W, Kim D, Dang CV, Levchenko A, Semenza GL. A non-transcriptional role of HIF-1α as a direct inhibitor of DNA replication. Science Signaling. 2013 Feb 12;6(262):ra10.

  • Fan DN, Tsang FH, Au SL, Wong CC, Wei LL, Lee JM, He X, Ng IO, Wong CM. SUV39H1 overexpression promotes HCC progression and is negatively regulated by microRNA-125b. Hepatology. 2013 Feb;57(2):637-47.

  • Chaturvedi P, Gilkes DM, Wong CC, Kschitiz, Zhang H, Wei H, Takano N, Schito L, Levchenko A, Semenza GL. Hypoxia-inducible factors promote metastasis by mediating bidirectional signaling between breast cancer cells and mesenchymal stem cells. Journal of Clinical Investigation. 2013 Jan 2;123(1):189-205.

2012

  • Schito L, Rey S, Tafani M, Zhang H, Wong CC, Russo A, Russo MA, Semenza GL. HIF-1-dependent PDGF-B expression promotes lymphatic metastasis of hypoxic breast cancer cells. Proceedings of National Academy of Sciences. 2012 Oct 2;109(40):E2707-16.

  • Ma W, Wong CC, Tung EK, Wong CM, Ng IO. RhoE is frequently downregulated in HCC and suppresses HCC invasion through antagonizing the Rho/ROCK/MYPT pathway. Hepatology. 2013 Jan;57(1):152-61.

  • Wong CC, Zhang H, Gilkes DM, Chen J, Wei H, Chaturvedi P, Hubbi M, Semenza GL. Inhibitors of Hypoxia-Inducible Factor 1 block breast cancer metastatic niche formation and lung metastasis. Journal of Molecular Medicine. 2012 Jul;90(7):803-15.

  • Au SL, Wong CC, Lee JM, Fan DN, Ng IO, Wong CM. Enhancer of zeste homolog 2 (EZH2) epigenetically silences multiple tumor suppressor miRNAs to promote liver cancer metastasis. Hepatology. 2012 Aug;56(2):622-31.

  • Wong CM*, Wong CC*, Lee JM, Fan DN, Au SL, Ng IO. Sequential alterations of miRNA expression in hepatocellular carcinoma development and venous metastasis. Hepatology. 2012 May;55(5):1453-61.

  • Zhang H, Wong CC, Wei H, Gilkes DG, Korangath P, Chaturvedi P, Schito L, Chen J, Krishnamachary, Winnard Jr P, Raman V, Zhen L, Mitzner W, Sukumar S, Semenza GL. HIF-1 dependent expression of angiopoietin-like 4 and LICAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.Oncogene. 2012 Apr 5;31(14):1757-70.

2008-2011

  • Wong CC, Gilkes DG, Zhang H, Chen J, Wei H, Chaturvedi P, Fraley SI, Wong CM, Khoo US, Ng IO, Wirtz D, Semenza GL. HIF-1 is a master regulator of breast cancer metastatic niche formation. Proceedings of National Academy of Sciences. 2011 Sep 27;108(39):16369-74.

  • Gao P, Wong CC, Lee JM, Tung EK, Wong CM, Ng IO. Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis. Journal of Hepatology. 2011 Jun; 54 (6): 1177-84.

  • Wong CM, Wong CC, Ng YL, Au SL, Ko FC, Ng IO. Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery. PLoS ONE.  2011 Feb 8;6(2):e16702.

  • Wong CC*, Wong CM*, Tung EK, Au SL, Lee JM, Man K, Ng IO.  MiR-139 suppresses metastasis and progression of hepatocellular carcinoma through regulation of Rho-kinase 2 (ROCK2). Gastroenterology. 2011 Jan;140(1):322-31. (Top 2% of published articles in biology and medicine, Faculty of 1000)

  • Wong CC, Wong CM, Tung EK, Man K, Ng IO.  Rho-kinase 2 (ROCK2) is frequently over-expressed in hepatocellular carcinoma and involved in tumor invasion.  Hepatology.  2009 May; 29 (5) 1583-94. 

  • Wong CC, Wong CM, Ko FC, Chan LK, Ching YP, Yam JW, Ng IO.  Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.  PLoS ONE.  2008 July 23; 3(7): e2779.

  • Lung HL, Lo CC, Wong CC, Cheung AK, Cheong KF, Wong N, Kwong FM, Chan KC, Law EW, Tsao SW, Chua D, Sham JS, Cheng Y, Stanbridge EJ, Robertson GP, Lung ML. Identification of tumor suppressive activity by irradiation microcell-mediated chromosome transfer and involvement of alpha B-crystallin in nasopharyngeal carcinoma. International Journal of Cancer. 2008 Mar; 122 (6): 1288-96.

  • Wong CM, Ng YL, Lee JM, Wong CC, Cheung OF, Chan CY, Tung EK, Ching YP, Ng IO. Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma. Hepatology. 2007 May; 45 (5): 1129-38.  
     

Review Articles, Book Chapters, and Commentaries:

  • Chan CY*, Yuen VW,* Wong CC. Hypoxia and the metastatic niche. Adv Exp Med Biol. 2019;1136-112. doi: 10.1007/978-3-030-12734-3_7. Review.

  • Chiu DK*, Zhang MS*, Tse AP*, Wong CC. Assessment of stabilization and activty of the HIFs important for hypoxia-Induced signallng in cancer cells. Methods Mol Biol. 2019; 1928:77-99. doi: 10.1007/978-1-4939-9027-6_6. Book chapter.

  • Wong CC, Wong CM, Ng IO. Hormonal control of the metabolic machinery of hepatocellular carcinoma. Hepatobiliary Surg Nutr. 2016 Jun; 5(3): 195-7.

  • Wong CC, Kai AK, Ng IO. The impact of hypoxia in hepatocellular carcinoma metastasis. Frontiers of Medicine. 2014 Mar;8(1):33-41.

  • Wong CC, Wong CM, Au SL, Ng IO. Rho GTPases and rho effectors in hepatocellular carcinoma Metastasis: ROCK N’ Rho Move it. Liver International. 2010 May;30(5):642-56.

  • Wong CC, Ng IO. Gene expression profiles in different stages of hepatocarcinogenesis. Journal of Gastroenterology and Hepatology. 2008 Jan; 23 (1): 1-3.