News

Congratulations to our mentor, Professor Gregg Semenza, for winning the Nobel Prize!

October 06, 2019

Professor Gregg Semenza is one of recipients of the Nobel Prize in Physiology or Medicine 2019 for his groundbreaking discovery of the oxygen sensing and adaptation system in mammalian cells. Oxygen is the most essential element in life. Professor Semenza discovered the key protein in the oxygen sensing system, hypoxia-inducible factor 1 (HIF-1), which enables cells to survive in low oxygen environment. His discovery has broad implications in the physiology and pathology of diseases including stroke and cancer. 

Genome wide CRISPR-Cas9 KO screening identified an important metabolic pathway responsible for Sorafenib resistance.

October 14, 2019

Sorafenib is a standard therapy for advanced liver cancer patients. However, most patients develop resistance towards Sorafenib. Using the CRISPR-Cas9 knockout library screening platform, we identified that the serine synthesis pathway (SSP) as the major metabolic pathway that enables liver cancer cells to survive under Sorafenib treatment. PHGDH is the first committed enzyme of the SSP pathway that diverts glycolytic metabolites into the SSP. PHGDH inhibitor greatly sensitizes liver cancer cells to Sorafenib treatment and inhibits liver cancer growth in mice. 

This joint work with Dr. Jack Wong's team has been recently published in Nature Communications. Congratulations to Larry for his publication! 

Carmen has been elected as a member of the Hong Kong Young Academy of Sciences (YASHK).

September 24, 2019

Annual Conference of International Liver Cancer Assocation at Chicago

September 20, 2019

Carmen received the Junior Investigator Award at the ILCA annual conference. Carmen presented David's work on the molecular mechanisms of immune checkpoint inhibitor resistance in liver cancer at the Young Investigator Session of ILCA.

FACT, histone chaperone, is responsible for NRF2-mediated transcription elongation

September 07, 2019

Our joint publication with Dr. Jack Wong's epigenetics lab has been accepted by GUT.  NRF2 is known to be a transcription factor and the major regulator that helps cells to overcome oxidative stress by initiating transcription of a repertoire of antioxidant genes. How NRF2 activates this adaptive response in an expeditious manner to ensure liver cancer cells survive high oxidative stress? 

In this work, we identified a histone chaperone, the FACT complex, is responsible for NRF2-mediated transcription elongation of antioxidant genes. NRF2 initiates transcription when liver cancer cells encounter oxidative stress. The FACT complex is stabilized by oxidative stress and is further induced by NRF2. With the FACT complex, nucleosome could be reassembled and disassembled quickly to allow RNA polymerase to pass through chromatin during elongation to accelerate antioxidant gene transcription. Excitingly, a FACT inhibitor, curaxin, is able to reverse the event and suppress liver cancer growth in our mouse model.

Congratulations to Jialing for her exciting finding being accepted for publication!

Histone chaperone FACT complex mediates oxidative stress response to promote liver cancer progression. Gut. 2019 Aug 22. pii: gutjnl-2019-318668. doi: 10.1136/gutjnl-2019-318668. [Epub ahead of print]

New metaboblic vulnerability in liver cancer

April 29, 2019

Recently, we found that liver cancer cells rely on the thioredoxin system to counteract oxidative stress. We also demonstrated that auranofin, an inhibitor that targets thioredoxin reductase 1 (TXNRD1) which is commonly used in arthritis, could be repurposed for liver cancer treatment as single treatment or as combined treatment with Sorafenib.

Congratulations to Derek for his new publication!

Induction of Oxidative Stress Through Inhibition of Thioredoxin Reductase 1 Is an Effective Therapeutic Approach for Hepatocellular Carcinoma. Hepatology. 2019 Apr;69(4):1768-1786. doi: 10.1002/hep.30467. 

Nerd Nite x CSA

July 21, 2019

Nerd Nite is a monthly lecture event that aims at a casual, relaxed, and slightly inebriated evening of academic fun times. The idea is for people to have a good time with friends over drinks while learning a thing or two, like the Discovery Channel – with beer!

Croucher scholars Kenneth Leung, Winston Sun and Carmen Wong spoke at Nerd Nite x CSA. 

Carmen gave a talk on "A journey from a childhood dream to reality - Do what you love. Love what you do"

Goodbye David!

July 30, 2019

David did his MPhil, PhD, and postdoctoral training in the team. We will remember the friendship, research excitements, and laughter we shared in the past 6 years. We built this team together. David has grown with the team. We thank David for his unreserved contribution to the team. We are and will be proud of David! Time to spread your wings! All the best to your future endeavors!! Continue to generate masterpieces! You will be missed dearly!

Pathology Departmental Research Postgraduate Students Retreat 2010

June 27, 2019

Congratulations to Macus for winning the Best Scientific Content Award and Cerise for winning the Most Translational Value Award. 

2019 Hong Kong Inter-U Postgraduate Symposium

June 07, 2019

Macus, Noreen, and Derek have won the Outstanding Poster Presentation Awards. Congratulations and keep up the good work!

Cerise and Derek were awarded scholarships.

April 25, 2019

Cerise has been awarded the YS and Christabel Lung Postgraduate Scholarship 2018/19. Derek has been awarded the Wong Ching Yee Medical Postgraduate Scholarship 2018/19. Congratulations! Keep up the good work.

Cerise was awarded the Leong Che Hung Medical and Research Enrichment Scholarship

April 14, 2019

Congratulations to Cerise! She has received an award from Professor Leong at the prize presentation ceremony. We thank Professor Leong for his encouragement, support, and generosity to our students.

Faculty Prize Presentation Ceremony

February 10, 2019

Congratulations to David for receiving the Dr KP Stephen Chang Gold Medal for the best PhD thesis in our faculty and the Chan To Haan Prize for Research Postgraduate Students in Pathology.

Congratulations to Jacinth for receiving the Dr. Veronica Lam Prize for her outstanding achievements in her undergraduate study at HKU. 

Noreen has won the best poster award in the HK Society of Flow Cytometry Annual Meeting

March 08, 2019

Noreen has received an award from Professor Kathy Lui in the  Annual Meeting of HK Society of Flow Cytometry. 

Our postdoctoral fellows have successfully secured two HMRF grants. Congratulations!

February 28, 2019

Big congrats to David and Misty for being awarded two external grants as principal investigators!  Thank you so much for the hard work.  

Hong Kong Institute of Science - Hong Kong Yong Scientist Presentation

November 30, 2018

David was selected as a finalist for the Hong Kong Young Scientist Award. He made a great presentation on hypoxia and myeloid-derived suppressor cells.

Research Postgraduate Symposium -HKU Faculty of Medicine

December 05, 2018

Cerise, Macus, and Noreen have won the Outstanding Poster Presentation Awards! Great job and congrats. Keep up your great work!

Award Presentation Ceremony 2018

December 11, 2018

David received the Li Ka Shing Prize for the best PhD thesis award. Big congratulations for your achievement!

Jacinth received the Lee Shau Kee Postgraduate Fellowship to support her PhD study. Congratulations!

Derek was awarded the YS and Christabel Lung Postgraduate Scholarship (2017/2018). Jacinth was awarded the HKU PhD Fellowship. Congratulations!

July 18, 2018

Postgraduate students from our team will be presenting at the InterU Postgradaute Symposium.

June 22, 2018

Noreen will be giving an oral presentation on the intersection of the Wnt and HIF pathways in HCC.

Cerise will be giving a poster presentation on aneuploidy and immune microenvironment in HCC.

Derek will be giving a poster presentation on antioxidant and HCC.

Cerise has successfully transferred her study from MPhil to PhD. Congratulations and keep up the good work!

June 12, 2018

2017 Award Presentation Ceremony

March 25, 2018

Carmen received the Outstanding Young Researcher Award (OYRA) 2016/17 of HKU.

State Key Laboratory for Liver Research Internal Meeting

March 23, 2018

Cerise is going to give a talk on "pushing ploidy to its limit as a therapeutic strategy in liver cancer" in the internal meeting of State Key Laboratory for Liver Research.

Cold Spring Harbor Asia- Cancer & Metabolism

March 25, 2018

Carmen will share the work on the identification of metabolic pathways responsible for tyrosine kinase inhibitor (TKI) resistance in liver cancer.

4th International Conference on Phase 1 and Early Phase Clinical Trials (ICPOEP 2018)

March 01, 2018

Carmen gave a talk on hypoxia in cancer and immune cells at ICPOEP 2018.

Congregation

December 16, 2017

Congrats to Misty and Iris for getting their PhDs.

The 1st Annual Scientific Symposium for MSCO (Macau Society of Clinical Oncology)

December 15, 2017

Carmen is going to give a talk on the Basic Biology of Immunotherapy: Checkpoint Therapy in the MSCO meeting.

Cerise and Derek won the Outstanding Poster Presentation Awards at the 22nd Research Postgraduate Symposium of the LKS Faculty of Medicine, HKU

December 06, 2017

Cerise and Derek shared their most recent work with other postgraduate students in the symposium.  Greatest support from all the team members. 

David has passed his PhD oral defense!

Congratulations to Dr. David Chiu! May the end of your PhD study be the start of your exciting journey of exploration.

International Liver Cancer Association 2017, Seoul, Korea

September 14, 2017

Carmen is going to give an oral presentation about the link of metabolic rewiring of cancer cells and immune components in liver cancer on September 15th, 2017.

Our paper integrating the knowledge of cancer metabolism and immunity is published in Nature Communications. Congratulations to David!

September 10, 2017

In this study, we found that hypoxic liver cancer cells express an ectoenzyme, ENTPD2, which converts extracellular ATP to AMP, thereby favoring the accumulation of myeloid-derived suppressor cells in the tumor microenvironment of liver cancer. This population of myeloid cells inhibit T cells, enabling the cancer cells to bypass immune surveillance. Excitingly, we found that ENTPD2 inhibitor improved the efficiency of anti-PD1 and anti-CTLA4 by unleashing T cells to combat HCC.

Our paper is published in JCI this month. Congratulations to Derek!

May 17, 2017

In this study, we identified folate cycle as a new metabolic vulnerability in liver cancer.

Alumini Interview by Graduate School- Hunting Hijackers

March 31, 2017

EMBO Worshop 2017

Carmen will be the speaker of the EMBO Workshop in Thiol Oxidation in Toxicity and Signaling in Spain this September. She will give a talk on metabolic reprogramming in liver cancer.  She will share our recent lab findings- The pentose phosphate pathway and folate cycle protect liver cancer cells from oxidative stress. 

Croucher Innovation Award 2017

December 07, 2016

Carmen won the Croucher Innovation Award 2017. The ceremony has taken place on December 8th, 2016. We are very grateful to the Croucher Foundation for their support to make our dreams real. 

Graduate School Award Presentation Ceremony 2016

Robin won the Li Ka Shing Prize (a gold medal for the best MPhil thesis award)!  Congratulations again!!! Watch his video!!

https://uvision.hku.hk/playvideo.php?mid=20643

Graduation Ceremony 2016

We are all very proud to have you as our first MPhil graduate. You did a wonderful job! Best wishes for your future endeavors!! Congratulations, Robin!

The 21st Postgraduate Symposium of the Faculty of Medicine, HKU

David got the 1st runner up award for his oral presentation at the postgraduate symposium.  Congratulations!! Research without limits, David! 

Professor Gregg Semenza wins Lasker Award

September 12, 2016

9/2016

Congratulations to our mentor, Prof Gregg Semenza, for receiving the 2016 Albert Lasker Basic Medical Research Award!  Congrats to Team HIF-1! 

Interview of Robin!

9/2016

Our MPhil student LAI Kit Ho, Robin, was awarded the Li Ka Shing Prize for the best MPhil thesis. Today, staffs from the Graudate School interviewed Robin for a short video. Big congrats to Robin for his wonderful work!

David presented in AACR 2016!

4/2016

Our PhD student, CHIU Kung Chun, David was selected for oral presentation in the Annual Meeting of AACR 2016. Today, he gave a presentation in AACR 2016, New Orleans.  David, you made us proud! 

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