“How To Start a Research Project” Workshop 2022 Graduation Ceremony and “Nurturing Scientific Research Talents in Hong Kong” Forum
03 September 2022
Carmen had the honour to participate in this event by The Hong Kong Young Academy of Sciences held at the Hong Kong Science Park. The event aimed to encourage high school students in Hong Kong to explore their interest in science.
Congratulations to all the students who won the 1-minute Video Competition!
SKLLR Internal Research Meeting 2022
20 August 2022
Our final-year PhD student Bowie beautifully presented her research works at this year's SKLLR Internal Research Meeting and was awarded the Best Oral Presentation Award!
This comes as a result of Bowie's hard work throughout her study. Congratulations on your achievement and a wonderful way to conclude your PhD journey, Bowie!
CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma
3 August 2022
Another recent paper published by our group showed that another cell cycle inhibitor, CFI-402275, which specifically suppressed TTK which is responsible for spindle assembly checkpoint (SAC), caused chromosome mis-segregation and aneuploidy in liver cancer cells. CFI-402275, has different mechanism-of-action from CFI-400945, it also induced the STING-mediated SASPs in liver cancer cells through DNA damage and micronuclei formation. CyTOF study showed that CFI-402275 induced NK and CD8+ T cell recruitment. Combined treatment of CFI-402275 with anti-PD-1 extended the survival of mice with aggressive HCC. The work is published in PNAS. Congratulations to Dr. Cerise Chan!
Polo-like kinase 4 inhibitor CFI-400945 suppresses liver cancer through cell cycle perturbation and eliciting antitumor immunity
3 August 2022
Our group has recently reported that an orally available and potent PLK4 inhibitor, CFI-400945, suppressed proliferating HCC cells by inhibiting centrosome duplication and promoting endoreplication. In addition to cell cycle inhibition, more interestingly, we found that CFI-400945 induced micronuclei formation, DNA damage, and cytosolic DNA which together induced the cytosolic DNA sensing pathway, the STING pathway, through cytosolic DNA sensor DDX41. STING activated NFKB and IRF3/7-mediated transcription of senescence-associated secretory phenotypes (SASPs) to drive the recruitment of various immune cells. We showed that CFI-400945 worked together with anti-PD-1 and anti-PD-L1 to suppress HCC growth. The work was recently published in Hepatology. Congratulations to Dr. Cerise Chan!
Carmen and Vincent Share their Mentor-Mentee Relationship
26 July 2022
As this year marks the 135th anniversary of the Faculty, Carmen was invited to share her working relationship with whom she describes as her “senior apprentice” Vincent. In the interview, both of them share with readers their first impressions of one another, memorable moments they share with one another, and other interesting topics.
Click the link below to read the full interview!
Thiol-Based Redox Regulation and Signaling - The Chemical Biology of Sulfur
12 July , 2022
Carmen was invited to speak in this year's "Thiol-Based Redox Regulation and Signaling" conference held in Castelldefels, Spain.
During the conference, Carmen delivered a talk titled "Redox Homeostasis in Hepatocellular Carcinoma and its Therapeutic Implications" where she shared our group's findings on redox balance and HCC treatment to our fellow colleagues from around the world!
Department of Pathology Research Postgraduate Students (RPGs)
08 July , 2022
Our students Grace and Carrie shared their exciting projects with the fellow department members in our Department's RPG Retreat. Grace was awarded the High Clinical Relevance Award.
Congratulations to Grace for her achievement and great presentations from everyone!
2022 Hong Kong Inter-University Postgraduate Symposium in Life Science
27 June, 2021
Our PhD students Vincent, Jacinth, Bowie, and Carrie gave poster presentations on their research studies in this year's Inter-University Postgraduate Symposium in Life Science. Vincent and Jacinth have been awarded the Poster Awards!
Congratulations to both and jobs well done by all students!!
Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer
09 June , 2022
A recent publication in Nature Communications by our post-doctoral fellow Dr Misty Zhang highlights macropinocytosis, the process of endocytosis, as a new metabolic mechanism used by hepatocellular carcinoma (HCC) cells to engulf extracellular proteins as source to support the indefinite proliferation of liver cancer cells under oxygen deprivation - a condition known as hypoxia. Our findings shed light on macropinocytosis as a novel and effective therapeutic target for HCC.
The study was recently featured by HKUMed and newspapers found in the links below. Congratulations Misty on the groundbreaking findings!
Launch Ceremony for InnoHK!
25 May, 2022
On May 25th 2022, InnoHK was officially launched at the InnoHK Launch Ceremony which marked a new milestone in HKSAR Government’s commitment to the promotion of the region’s I&T! It is our honour to have the opportunity to be a part of this research and innovation program under the Centre for Oncology and Immunology (COI) co-directed by Prof Tak Mak and Prof Suet-Yi Leung.
New co-editor-in-chief for Hepatology Communications!
23 May, 2022
Dr. Elliot Tapper and Carmen will serve as new Co-Editor-in-Chiefs for Hepatology Communications, an official journal of the American Association for the Study of Liver Diseases (AASLD). We look forward in seeing your exciting work at Hepatology Communications soon!
Jacinth and Vincent received the YS and Christabel Lung Postgraduate Scholarship!
23 February, 2022
Jacinth and Vincent, our final-year PhD students, received the YS and Christabel Lung Postgraduate Scholarship 2021-22 in recognition of their academic excellence over the past year.
Proud of your achievement and big congratulations!
SKLLR/TRS Internal Research Meeting 2021
11 December, 2021
Our postdoc Dr Cerise and PhD student Jacinth have shared their wonderful research works in the SKLLR/TRS Internal Research Meeting. Congratulations to Jacinth for awarding the Best Oral Presentation Award! Well done!
26th Research Postgraduate Symposium (RPS) -
Li Ka Shing Faculty of Medicine, HKU
1-2 December, 2021
Our students Vincent, Jacinth, Bowie and Carrie have shared their great works in the 26th Research Postgraduate Symposium held on 1 and 2 December. Vincent was awarded the Outstanding Oral Presentation Award! Congratulations Vincent and keep up the great work!
Carmen's presentation at the Hong Kong Laureate Forum
14 September, 2021
Carmen shared our lab's latest research works and experience on cancer immunotherapies at the Science Exposition – Life Science and Medicine at the Hong Kong Laureate Forum. Check out some of the sights and sounds of the event below!
Vincent awarded Li Po Chun Charitable Trust Fund Postgraduate Scholarship!
15 August, 2021
Vincent, our PhD student, was recently awarded his 2nd Li Po Chun Charitable Trust Fund Postgraduate Scholarship. This Scholarship was originally awarded to Vincent last year and renewed this year in recognition of his impressive academic achievements.
Huge congratulations and great work, Vincent!
Carmen's latest interview with HKUMed
29 July, 2021
Carmen was recently interviewed by HKUMed talking about her scientific research journey. Carmen discussed her aspirations and passion towards liver cancer research. She also shared her career path and gave inspiring advices for young researchers.
You can find the complete interview posted on HKUMed's Official WeChat.
Li Ka Shing Prize, 2019-20
July 22, 2021
Derek was selected as one of the recipients of the Li Ka Shing Prizes for the 2019-20 academic year. This is an award of recognition for having one of the best PhD thesis from Science, Medicine, Engineering and Technology.
Congratulations on this huge honour, Derek!
Visiting our new lab @ Science Park!
July 15, 2021
We visited the laboratories and facilities of the Centre for Oncology and Immunology (COINNO) in the Hong Kong Science Park! We are extremely proud to be a part of The Centre funded by InnoHK. We are grateful for this huge support and are excited to begin this innovative journey in cancer immunology research!
Department of Pathology Research Postgraduate Students (RPGs)
July 9, 2021
Our PhD students Bowie, Jacinth, and Vincent participated in our Department's RPG Retreat. All 3 of them enthusiastically shared their studies to fellow department members. Vincent was awarded the Most Innovative Award.
Congratulations to Vincent for his achievement and the excellent presentations from everyone! Keep it up!
Immunology, immunotherapies, and cancer
July 3, 2021
Carmen delivered an informative lecture on cancer immunology during the Immunology - the Organ for All Seasons. seminar on Saturday, July 3. Her lecture entitled Immunology, immunotherapies, and cancer highlighted the exciting and latest findings from our group in this field.
Keep up with the amazing discoveries, team!
Immunology Seminar - the Organ for All Season
June 18, 2021
Carmen will be presenting in the Immunology Seminar held on 3 July, 2021 (Saturday) 2 - 5pm. She will talk about immunology, immunotherapies, and cancer. Find out more in the following link!
Hong Kong Inter-University Postgraduate Symposium 2021
June 12, 2021
Our PhD students Vincent, Jacinth and Bowie gave poster presentations on their research studies in the Inter-U Postgraduate Symposium this year. Vincent has been awarded the Out-standing Poster award! Well done Vincent!
RGC Postdoctoral Fellowship 2021-2022
April 26, 2021
Congratulations to Derek for being awarded the RGC Postdoctoral Fellowship (2021-2022). It is an honour that his research effort is being recognised by the Research Grants Council. We thank the RGC for supporting our Post-doc to continue his meaningful research!
We are very proud of you, Derek!
The International Liver Congress
April 21, 2021
Carmen will also be presenting in The International Liver Congress held on June 23-26, 2021. During the Metabolism and Cancer session, she will share our findings on KEAP1/NRF2-mediated oxidative stress response in liver cancer on Saturday June 26, 2021 2:15pm CET (Saturday June 26, 2021 8:15pm Hong Kong Time). Click below for more details!
Virtual KEYSTONE SYMPOSIA
April 21, 2021
Carmen will be presenting in the upcoming KEYSTONE SYMPOSIA - Cancer Stem Cells: Advances in Biology and Clinical Translation held on May 19-21, 2021. She will talk about Hypoxia, Cancer and Cancer Stemness on Friday May 21, 2021 at 8pm Hong Kong Time. Find out more at the link below!
YS and Christabel Lung Postgraduate Scholarship for Vincent!
April 20, 2021
Our PhD student, Vincent, has been awarded the YS and Christabel Lung Postgraduate Scholarship. It is truly a great recognition for his hard work. Congratulations!
Keep up with great work!
Cerise has passed her PhD oral defense!
March 5, 2021
Cerise passed her oral defence today and has officially become Dr. Cerise Chan! She put in tremendous efforts to reach this achievement since joining our lab. Congratulations, Dr Chan! We are all so proud of you! She has started her new chapter as a postdoctoral fellow in our laboratory to continue her exploration on finding innovative HCC therapies that could ignite the innate immune cells.
Chan To Haan Prize for Research Postgraduate Students in Pathology 2019-2020
Feb 10, 2021
Congratulations to Derek for being awarded the Chan To Haan Prize for Research Postgraduate Students in Pathology (2019-2020) as he was selected as the best graduating student based on his research output portfolio and thesis grading.
We are very proud of your continued hard work and achievements, Derek!
Genome-wide CRISPR-Cas9 knockout library screening identified PTPMT1 in cardiolipin synthesis is crucial to survival in hypoxia in liver cancer
January 26, 2021
Hypoxia, oxygen deprivation, is an important feature in solid tumors, especially liver cancer. Hypoxia is associated with tumor aggressiveness and therapy resistance. We performed genome-wide CRISPR-Cas9 library screening and identified PTPMT1, an important enzyme for cardiolipin (CL) synthesis, as a novel therapeutic target for survival of liver cancer cells under hypoxia. CL makes up the mitochondrial membrane where it stabilizes ETC complexes to prevent electron leakage and excessive ROS accumulation under hypoxia. Inhibition of PTPMT1 greatly induced oxidative stress and suppressed growth of not only liver cancer, but also other solid tumors.
This study was driven by our MPhil graduate Macus and Dr. Larry Wei in collaboration with Dr. Jack Wong's team. The study was recently published in Cell Reports. Congratulations Macus and Larry, amazing work!
Dr. KP Stephen Chang Gold Medal 2019/2020
January 11, 2021
Congratulations to Derek for being selected as the recipient of the Dr. KP Stephen Chang Gold Medal (Best PhD Thesis Award) from the Faculty of Medicine, HKU. His thesis title is "Adaptive and Constitutive Activations of Antioxidant-producing Metabolic Pathways in Hepatocellullar Carcinoma". In the past 4 years, he has discovered the major molecular mechanisms that lead to the metabolic alterations in the folate cycle and malate metabolism, generating NADPH which stabilizes antioxidant thioredoxin to allow liver cancer cells to overcome oxidative stress challenge. His work has led to the identification of novel therapeutic strategies that might potentially impede liver cancer progression.
We are very proud of you, Derek!
Tomorrow's Scientists Exploration Camp of the Hong Kong Laureate Forum
The inaugural Hong Kong Laureate Forum will take place on 15-20 Nov 2021. The forum has invited Shaw Laureates and renowned scientists to share their research and their journey in scientific explorations with 200 young scientists around the globe. This is going to be an exciting program with seminars, group discussions, workshops, and poster sessions.
To kick off, Tomorrow's Scientists Exploration Camp of the Hong Kong Laureate Forum has started on 5 Jan 2021. Due to COVID-19, our program was launched online. In this program, Carmen and Sean (Assistant Professor of Mathematics at Hong Kong Baptist University) have shared their experience with 60 local undergraduate students who are keen to pursue science and who will be selected to join the inaugural Hong Kong Laureate Forum. The participants have been very active with many questions. Due to the time constraint, we were not able to answer all questions. But, don't hesitate to contact us if you have more questions or doubts about your choice and directions.
We thank the council of the Hong Kong Laureate Forum for inviting us to be part of this meaningful event. It will be an exciting program. Stay tuned.
December 22, 2020
Congratulations to Derek for getting his PhD degree and Noreen for her MPhil degree! Thank you for the hard work in the past years and for leaving us so many good memories.
Noreen has started her MBBS study at HKU and Derek has started his postdoctoral training in our lab continuing his research journey with metabolic reprogramming in liver cancer.
May the memorable graduation mark the beginning of your success in your new endeavors!
Departmental Seminar by Dr Misty Zhang
December 17, 2020
Our post-doctoral fellow Misty will share her project titled "Hypoxia-induced Macropinocytosis Represents a New Metabolic Route for Liver Cancer" in the upcoming Departmental Seminar.
Feel free to register for the seminar delivered by Zoom on 17 December 2020 (Thursday) at 13:00!
25th Research Postgraduate Symposium (RPS) -
Li Ka Shing Faculty of Medicine, HKU
December 02-03, 2020
The 25th Research Postgraduate Symposium was held on 2 and 3 December. Our students have shared their exciting works to the faculty. Our PhD student Vincent was awarded the Outstanding Poster Presentation Award! Congratulations Vincent and keep up the great work!